(R)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)aMino)propanoate

CAS NO.：1714114-25-6
Empirical Formula: C18H17F5NO5P
Molecular Weight: 453.3

What is (R)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)aMino)propanoate?

The Uses of (R)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)aMino)propanoate

N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-D-alanine 1-Methylethyl Ester is an impurity of PSI-7977 (P839640); a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Properties of (R)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)aMino)propanoate

Boiling point:	442.6±55.0 °C(Predicted)
Density	1.405±0.06 g/cm3(Predicted)
pka	-3.81±0.70(Predicted)

Safety information for (R)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)aMino)propanoate

Computed Descriptors for (R)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)aMino)propanoate

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product: 1714114-25-6 Sofosubuvir Impurity- 108/Sofosbuvir Impurity 132 NLT 95%

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