(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

Chemical properties

white to faintly yellow crystalline powder

The Uses of (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

suzuki reaction

The Uses of (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

What are the applications of Application

(R)-(+)-Diphenyl-2-pyrrolidinemethanol is Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

Definition

ChEBI: (r)-alpha,alpha-diphenyl-2-pyrrolidinemethanol is a diarylmethane.

Synthesis

Draw 14 kg of tetrahydrofuran into the reaction kettle. 61.5 kg of a 34% strength solution of phenylmagnesium chloride in tetrahydrofuran was added to the reaction vessel to initiate agitation and cooling cycles. The control temperature is 10 to 60 °C. The dropping time was controlled for 5 to 6 hours, and stirring was continued for 1 hour. Pump 24 kg of concentrated hydrochloric acid (mass concentration 36%) into the matching drip tank of the reaction kettle. constantly dropping, the dropping time is controlled for 1 hour, and the dropping process control temperature does not exceed 45 ° C. After the addition was completed, stirring was continued for 8 hours.Cool down to -5 ° C ~ 5 ° C to obtain (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol, a total of 17.2 kg, yield 85%.