R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Synonym(s):R-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

CAS NO.：67287-39-2
Empirical Formula: C16H16ClNO2.BrH
Molecular Weight: 370.67
MDL number: MFCD00671792
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:54:11

R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Structural

What is R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide?

The Uses of R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

SKF 81297C is a dopamine D1 agonist (1).

Hazard

A poison.

Biological Activity

skf 81297 hydrobromide is a selective agonist of the dopamine d1-like receptor, with a ki value of 1.9 nm. the dopamine d1-like receptors, consisting of d1 and d5 subtypes, are a subfamily of dopamine receptors that mediate excitatory neurotransmission after binding the endogenous neurotransmitter dopamine. the dopamine d1-like receptors have been implicated in dopaminergic regulation of a variety of fundamental neurophysiologic processes including mood, motivation, cognitive function, as well as motor activity.1. neumeyer jl, kula ns, bergman j, baldessarini rj. receptor affinities of dopamine d1 receptor-selective novel phenylbenzazepines. european journal of pharmacology, 2003, 474(2-3): 137-140.2. undieh as. pharmacology of signaling induced by dopamine d(1)-like receptor activation. pharmacology & therapeutics, 2010, 128(1): 37-60.3. vermeulen rj, drukarch b, sahadat mc, et al. the dopamine d1 agonist skf 81297 and the dopamine d2 agonist ly 171555 act synergistically to stimulate motor behavior of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinsonian rhesus monkeys. movement disorders, 1994, 9(6): 664-672.

Storage

+4°C (desiccate)

Properties of R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Melting point:	>256°C (dec.)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	H₂O: 6 mg/mL
form	solid
color	white to off-white

Safety information for R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Computed Descriptors for R(+)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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