(R)-1-Boc-3-methylpiperazine
Synonym(s):tert-Butyl (R)-3-methyl-1-piperazinecarboxylate
- CAS NO.：163765-44-4
- Empirical Formula: C10H20N2O2
- Molecular Weight: 200.28
- MDL number: MFCD02683205
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:37
What is (R)-1-Boc-3-methylpiperazine?
Chemical properties
White solid
The Uses of (R)-1-Boc-3-methylpiperazine
(R)-4-Boc-2-methylpiperazine is a reagent used in organic synthesis. Used in the synthesis of orally bioavailable inhibitors of 11-β-hydroxysteroid
Synthesis
To a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 ℃ was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL), followed by extraction into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4), and concentrated to give (R)-1-Boc-3-methylpiperazine as a white solid (669 mg, 84%).
Properties of (R)-1-Boc-3-methylpiperazine
| Melting point: | 40-45 °C |
| Boiling point: | 268.7±15.0 °C(Predicted) |
| Density | 0.997±0.06 g/cm3(Predicted) |
| Flash point: | 223 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | Crystalline Powder |
| pka | 8.52±0.40(Predicted) |
| color | White |
| optical activity | [α]/D +16±2°, c = 1 in dioxane |
| CAS DataBase Reference | 163765-44-4(CAS DataBase Reference) |
Safety information for (R)-1-Boc-3-methylpiperazine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-1-Boc-3-methylpiperazine
| InChIKey | FMLPQHJYUZTHQS-MRVPVSSYSA-N |
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