(R)-3-Hydroxypyrrolidine
Synonym(s):(R)-3-Hydroxypyrrolidine
- CAS NO.：2799-21-5
- Empirical Formula: C4H9NO
- Molecular Weight: 87.12
- MDL number: MFCD00145220
- EINECS: 628-839-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-28 17:34:51
What is (R)-3-Hydroxypyrrolidine?
Chemical properties
clear yellow to orange-brown viscous liquid
The Uses of (R)-3-Hydroxypyrrolidine
(R)-Pyrrolidin-3-ol is used in preparation of allosteric BCR-ABL bifunctional proteolysis targeting chimera compounds.
What are the applications of Application
(R)-3-Pyrrolidinol is a ligand in the enantioselective addition of diethylzinc to aromatic aldehydes
Purification Methods
The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]
Properties of (R)-3-Hydroxypyrrolidine
| Melting point: | 15°C |
| Boiling point: | 215-216 °C (lit.) |
| alpha | 6.5 º (c=3.5% in MeOH) |
| Density | 1.078 g/mL at 20 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Viscous Liquid |
| pka | 14.91±0.20(Predicted) |
| Specific Gravity | 1.048 |
| color | Clear yellow to orange-brown |
| optical activity | [α]20/D +6.5°, c = 3.5 in methanol |
| Water Solubility | Soluble in water and methanol. |
| Sensitive | Air Sensitive & Hygroscopic |
| BRN | 5376132 |
| CAS DataBase Reference | 2799-21-5(CAS DataBase Reference) |
Safety information for (R)-3-Hydroxypyrrolidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see … on this label). P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for (R)-3-Hydroxypyrrolidine
(R)-3-Hydroxypyrrolidine manufacturer
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