(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE
Synonym(s):D -α,β-Isopropylideneglycerol-γ-tosylate;1,2-Isopropylidene-sn-glycerol 3-tosylate
- CAS NO.：23788-74-1
- Empirical Formula: C13H18O5S
- Molecular Weight: 286.35
- MDL number: MFCD00063233
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:29:18
What is (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE?
Chemical properties
clear yellow to light brown viscous liquid
The Uses of (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE
(R)-(-)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate is a chiral building block. It is used to prepare the antifungal agent ketoconazole. It is also used to prepare acyclic Nucleotide Analogs Derived from 8-Azapurines with antiviral activities.
Properties of (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE
| Melting point: | 41-43 °C(lit.) |
| Boiling point: | 398.71°C (rough estimate) |
| Density | 1.208 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | -20°C |
| solubility | Dichloromethane; Chloroform; Ethyl Acetate; Methanol; DMF; |
| form | Oil |
| color | Pale Brown |
| optical activity | [α]/D 7.0±0.5°, neat |
| BRN | 89800 |
| CAS DataBase Reference | 23788-74-1(CAS DataBase Reference) |
Safety information for (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE
| InChIKey | SRKDUHUULIWXFT-LLVKDONJSA-N |
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