R 112 (pharMaceutical)
- CAS NO.：575474-82-7
- Empirical Formula: C16H13FN4O2
- Molecular Weight: 312.3
- MDL number: MFCD12922519
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is R 112 (pharMaceutical)?
Description
R112 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4; ) and decreases cytokine levels in cultured human mast cells.
The Uses of R 112 (pharMaceutical)
R 112 is Syk inhibitor. It can be used in biological study and therapeutic use of application of cultured human mast cells (CHMC) for design and structure-activity relationship of IgE-mediated mast cell activation inhibitors.
Properties of R 112 (pharMaceutical)
| Boiling point: | 552.0±60.0 °C(Predicted) |
| Density | 1.494±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:30.0(Max Conc. mg/mL);96.1(Max Conc. mM) |
| form | A crystalline solid |
| pka | 9.48±0.10(Predicted) |
| color | Light yellow to yellow |
Safety information for R 112 (pharMaceutical)
Computed Descriptors for R 112 (pharMaceutical)
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