(R)-(-)-1-Phenyl-1,2-ethanediol
Synonym(s):(−)-Styrene glycol;(R)-(−)-Phenylethylene glycol
- CAS NO.：16355-00-3
- Empirical Formula: C8H10O2
- Molecular Weight: 138.16
- MDL number: MFCD00064262
- EINECS: 202-258-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:33
What is (R)-(-)-1-Phenyl-1,2-ethanediol?
Chemical properties
white to light yellow crystal powde
The Uses of (R)-(-)-1-Phenyl-1,2-ethanediol
(R)-(-)-1-Phenyl-1,2-ethanediol is an intermediate for the synthesis of enantiopure substituted 1,4-Dioxanes. Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis.
The Uses of (R)-(-)-1-Phenyl-1,2-ethanediol
Intermediate for the synthesis of chiral phosphine catalysts for asymmetric hydrogenations.
Purification Methods
Purify the diol by recrystallisation from *C6H6/ligroin and sublime it at 1-2mm. [Arpesella et al. Gazetta 85 1354 1955, Prelog et al. Helv Chim Acta 37 221 1954, Beilstein 6 IV 5939.]
Properties of (R)-(-)-1-Phenyl-1,2-ethanediol
| Melting point: | 64-67 °C(lit.) |
| Boiling point: | 272-274 °C(lit.) |
| alpha | -69 º (c=1, chloroform) |
| Density | 1.0742 (rough estimate) |
| refractive index | -40 ° (C=3, H2O) |
| Flash point: | 272-274°C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.61±0.20(Predicted) |
| color | Off-White |
| optical activity | [α]20/D 69°, c = 1 in chloroform |
| Water Solubility | SOLUBLE |
| Merck | 14,8861 |
| BRN | 2355547 |
| CAS DataBase Reference | 16355-00-3(CAS DataBase Reference) |
Safety information for (R)-(-)-1-Phenyl-1,2-ethanediol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-(-)-1-Phenyl-1,2-ethanediol
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