(R)-1-N-Boc-2-(hydroxymethyl)piperazine

CAS NO.：169448-87-7
Empirical Formula: C10H20N2O3
Molecular Weight: 216.28
MDL number: MFCD07772092
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:59:17

What is (R)-1-N-Boc-2-(hydroxymethyl)piperazine?

The Uses of (R)-1-N-Boc-2-(hydroxymethyl)piperazine

(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate is used in preparation of novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof.

Synthesis

Lithium aluminum hydride (1M in THF, 26 ml) was added to a solution of L-TERT- butyl 2-methyl (2R)-piperazine-1, 2-dicarboxylate (2. 55 g) in THF (70 ml) at-40°C, and then the reaction was warmed to room temperature. After stirring for 1 h, this reaction system was cooled to 0°C and quenched by sequential addition of water (1 ml), sodium hydroxide (2N, 1 ml), and then water (2 ml). The resulting slurry was filtered and concentrated in vacuo to give (R)-1-N-Boc-2-(hydroxymethyl)piperazine.

Properties of (R)-1-N-Boc-2-(hydroxymethyl)piperazine

Boiling point:	324.0±17.0 °C(Predicted)
Density	1.085±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
pka	14.97±0.10(Predicted)

Safety information for (R)-1-N-Boc-2-(hydroxymethyl)piperazine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.