Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)-

CAS NO.：1904651-39-3
Empirical Formula: C14H15F2N3
Molecular Weight: 263.29
Update Date: 2025-07-16 09:55:40

What is Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)-?

The Uses of Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)-

7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-1,2,3,4-tetrahydroquinoline is an intermediate in the synthesis of GNE-781 (D447825), a derivative of a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology.

Properties of Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)-

Boiling point:	440.6±45.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
solubility	Dichloromethane; Ethyl Acetate; Methanol
pka	3.96±0.20(Predicted)
form	Solid
color	Off-White

Safety information for Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)-

Computed Descriptors for Quinoline, 7-(difluoromethyl)-1,2,3,4-tetrahydro-6-(1-methyl-1H-pyrazol-4-yl)-

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