Quinaldic acid
Synonym(s):2-Quinolinecarboxylic acid
- CAS NO.：93-10-7
- Empirical Formula: C10H7NO2
- Molecular Weight: 173.17
- MDL number: MFCD00006752
- EINECS: 202-218-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 15:00:32
What is Quinaldic acid?
Chemical properties
light brown needle-like crystalline powder
The Uses of Quinaldic acid
For the determination of copper, zinc and uranium with which it forms insoluble salts.
The Uses of Quinaldic acid
2-?Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.
Definition
ChEBI: A quinolinemonocarboxylic acid having the carboxy group at the 2-position.
Synthesis Reference(s)
Journal of the American Chemical Society, 68, p. 1840, 1946 DOI: 10.1021/ja01213a045
General Description
Quinaldic acid is also referred as quinoline-2-carboxylic acid. Microwave-assisted preparation of substituted anilides of quinaldic acid has been reported. It inhibits the oxidation of pyruvate, α-ketoglutarate, glutamate and citrate in rat liver mitochondria. Quinaldic acid is a metabolite of tryptophan degradation and inhibits the gluconeogenesis in perfused livers.
Purification Methods
Crystallise quinaldic acid from *C6H6 or AcOH. It is used for the estimation of many metals. The methyl ester has m 86-87o (from hexane) and pK25 1.76. [Chauduri et al. Frez Z Anal Chem 281 361 1976, Beilstein 22 H 71, 22 II 55, 22 III/IV 1149, 22/3 V 183.]
Properties of Quinaldic acid
| Melting point: | 156-158 °C (lit.) |
| Boiling point: | 247-250 |
| Density | 1.2427 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 14g/l |
| pka | 1.20±0.30(Predicted) |
| form | Needle-Like Crystalline Powder |
| color | Light brown |
| PH | 3.0-3.5 (10g/l, H2O, 20℃) |
| Water Solubility | soluble |
| Merck | 14,8046 |
| BRN | 126322 |
| CAS DataBase Reference | 93-10-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Quinolinecarboxylic acid(93-10-7) |
| EPA Substance Registry System | 2-Quinolinecarboxylic acid (93-10-7) |
Safety information for Quinaldic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Quinaldic acid
Quinaldic acid manufacturer
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