Quinaldic acid

Synonym(s):2-Quinolinecarboxylic acid

CAS NO.：93-10-7
Empirical Formula: C10H7NO2
Molecular Weight: 173.17
MDL number: MFCD00006752
EINECS: 202-218-3
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-07 19:09:50

What is Quinaldic acid?

Chemical properties

light brown needle-like crystalline powder

The Uses of Quinaldic acid

For the determination of copper, zinc and uranium with which it forms insoluble salts.

The Uses of Quinaldic acid

2-?Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.

Definition

ChEBI: A quinolinemonocarboxylic acid having the carboxy group at the 2-position.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1840, 1946 DOI: 10.1021/ja01213a045

General Description

Quinaldic acid is also referred as quinoline-2-carboxylic acid. Microwave-assisted preparation of substituted anilides of quinaldic acid has been reported. It inhibits the oxidation of pyruvate, α-ketoglutarate, glutamate and citrate in rat liver mitochondria. Quinaldic acid is a metabolite of tryptophan degradation and inhibits the gluconeogenesis in perfused livers.

Purification Methods

Crystallise quinaldic acid from *C6H6 or AcOH. It is used for the estimation of many metals. The methyl ester has m 86-87o (from hexane) and pK25 1.76. [Chauduri et al. Frez Z Anal Chem 281 361 1976, Beilstein 22 H 71, 22 II 55, 22 III/IV 1149, 22/3 V 183.]

Properties of Quinaldic acid

Melting point:	156-158 °C (lit.)
Boiling point:	247-250
Density	1.2427 (rough estimate)
refractive index	1.5200 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	14g/l
pka	1.20±0.30(Predicted)
form	Needle-Like Crystalline Powder
color	Light brown
PH	3.0-3.5 (10g/l, H2O, 20℃)
Water Solubility	soluble
Merck	14,8046
BRN	126322
CAS DataBase Reference	93-10-7(CAS DataBase Reference)
NIST Chemistry Reference	2-Quinolinecarboxylic acid(93-10-7)
EPA Substance Registry System	2-Quinolinecarboxylic acid (93-10-7)

Safety information for Quinaldic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.