QUINACRINE DIHYDROCHLORIDE DIHYDRATE

The Uses of QUINACRINE DIHYDROCHLORIDE DIHYDRATE

anthelmintic, antimalarial, intercalating agent

The Uses of QUINACRINE DIHYDROCHLORIDE DIHYDRATE

Quinacrine is an acridine that was used extensively from the mid-1920s to the end of World War II. It acts much like chloroquine and is reasonably effective. Because it causes the skin to turn yellow and, in high doses, causes yellow vision, the drug is no longer in use as an antimalarial.

Definition

ChEBI: A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.

Safety Profile

Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. Experimental reproductive effects. Has been implicated in aplas tic anemia. When heated to decomposition, it emits very toxic fumes of Cland NOx.