Quetiapine fumarate
Synonym(s):2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate;Quetiapine fumarate;Quetiapine hemifumarate salt
- CAS NO.：111974-72-2
- Empirical Formula: C25H29N3O6S
- Molecular Weight: 499.58
- MDL number: MFCD03423782
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-18 14:37:43
What is Quetiapine fumarate?
Description
Quetiapine hemifumarate (111974-72-2) is an atypical antipsychotic agent. Antagonist at serotonin (5-HT2) and dopamine (D2) receptors, IC50s=148 and 329 nM respectively. Reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation in a rat model. Efficacious as a monotherapy in the treatment of posttraumatic stress disorder.
The Uses of Quetiapine fumarate
Used as an antipsychotic. Quetiapine fumarate is a psychotropic agent belonging to a chemical class, the dibenzothiazepine derivatives. It is present in tablets as the fumarate salt. It's activity is primarily due to the parent drug. Quetiapine has affinity for D2, 5-HT2A, H1, alpha 1 and 5-HT1A receptors.
Properties of Quetiapine fumarate
| Melting point: | 174-176°C |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: >10mg/mL |
| form | powder |
| color | white to off-white |
Safety information for Quetiapine fumarate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H400:Hazardous to the aquatic environment, acute hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Quetiapine fumarate
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Cefa-Cilinas Biotics Pvt Ltd
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Phone:+91-8080701561
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