QUERCETIN-3-O-GLUCURONIDE
- CAS NO.：22688-79-5
- Empirical Formula: C21H18O13
- Molecular Weight: 478.36
- MDL number: MFCD09752939
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-27 19:03:18
What is QUERCETIN-3-O-GLUCURONIDE?
Description
Quercetin 3-O-glucuronide is a pharmacologically active flavonol glucuronide isolated from H. perforatum (St. John’s wort) that inhibits the α2c adrenergic receptor (Ki = 4,060 nM in hα2c preparations). Quercetin 3-O-glucuronide (0.6 mg/kg) reduced the time rats spent immobile in the forced swim test, suggesting antidepressant-like properties, when given either acutely or chronically. It also reduced open field stress-induced hyperthermia in mice (at 1.2 mg/kg).
Chemical properties
Yellow Solid
The Uses of QUERCETIN-3-O-GLUCURONIDE
Quercetin 3-O-β-D-Glucuronide is the major metabolite of Quercetin (Q509500).
Definition
ChEBI: Miquelianin is a quercetin O-glycoside that consists of quercetin attached to a beta-D-glucuronopyranosyl moiety at position 3 via a glycosidic linkage. Isolated from Salvia and Phaseolus vulgaris, it exhibits antioxidant and antidepressant activities. It has a role as a metabolite, an antioxidant and an antidepressant. It is a beta-D-glucosiduronic acid and a quercetin O-glycoside.
Properties of QUERCETIN-3-O-GLUCURONIDE
| Melting point: | 193～195℃ |
| Boiling point: | 927.8±65.0 °C(Predicted) |
| Density | 1.96±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | neat |
| pka | 2.76±0.70(Predicted) |
| form | Solid |
| color | Yellow to Very Dark Yellow |
| Stability: | Very Hygroscopic |
Safety information for QUERCETIN-3-O-GLUCURONIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H317:Sensitisation, Skin H370:Specific target organ toxicity, single exposure H372:Specific target organ toxicity, repeated exposure H373:Specific target organ toxicity, repeated exposure H402:Hazardous to the aquatic environment, acute hazard |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P272:Contaminated work clothing should not be allowed out of the workplace. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for QUERCETIN-3-O-GLUCURONIDE
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