QN523

CAS NO.：878581-60-3
Empirical Formula: C14H10N4O
Molecular Weight: 250.26
Update Date: 2026-07-16 07:06:08

What is QN523?

Biological Activity

QN523 is an anticancer agent.1 It is cytotoxic to MiaPaCa-2, PANC-1, and BxPC-3 pancreatic cancer cells (IC50s = 0.11, 0.5, and 3.3 μM, respectively). QN523 (0.5 μM) induces cell cycle arrest at the S phase in MiaPaCa-2 cells. It increases levels of the endoplasmic reticulum (ER) stress markers glucose-regulated protein 78 kDa (GRP78), DNA damage inducible transcript 3 (DDIT3), activating transcription factor 3 (ATF3), and growth differentiation factor 15 (GDF15), as well as the autophagy markers WD repeat domain phosphoinositide-interacting protein 1 (WIPI1), GABAA receptor-associated protein-like 1 (GABARAPL1), and LC3-II in MiaPaCa-2 cells in a concentration-dependent manner. QN523 reduces tumor volume in a MiaPaCa-2 mouse xenograft model.

References

1.Kuang, Y., Ye, N., Kyani, A., et al.Induction of genes implicated in stress response and autophagy by a novel quinolin-8-yl-nicotinamide QN523 in pancreatic cancerJ. Med. Chem.65(8)6133-6156(2022)

Properties of QN523

Boiling point:	381.8±27.0 °C(Predicted)
Density	1.374±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMF: 5 mg/ml,DMSO: 2 mg/ml
form	A crystalline solid
pka	10.38±0.43(Predicted)
color	Light brown to brown

Safety information for QN523

Computed Descriptors for QN523

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