Pyrimidinetetramine sulfate
- CAS NO.：5392-28-9
- Empirical Formula: C4H10N6O4S
- Molecular Weight: 238.22
- MDL number: MFCD00012786
- EINECS: 226-393-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:57
What is Pyrimidinetetramine sulfate?
Chemical properties
Light yellow crystal powder
The Uses of Pyrimidinetetramine sulfate
Intermediate in the production of Methotrexate
The Uses of Pyrimidinetetramine sulfate
2,4,5,6-Tetraaminopyrimidine Sulfate is an intermediate for the synthesis of the antitumor drugs methotrexate and fludarabine.
Purification Methods
Purify the salt by recrystallisation from H2O, 2N H2SO4 (20 parts, 67% recovery) or 0.1N H2SO4 (40 parts, 62% recovery), and dried in air. [UV: Konrad & Pfleiderer Chem Ber 103 722 1970, Malletta et al. J Am Chem Soc 69 1814 1947, Cavalieri et al. J Am Chem Soc 70 3875 1948, Beilstein 25 H 423, 25 III/IV 3106.]
References
[1] SAUMYA SHUKLA. Toxic potential assessment of hair dye developer 2,4,5,6-tetraaminopyrimidine sulfate exposed under ambient UVB radiation.[J]. Toxicology and Industrial Health, 2024: 1-8. DOI:10.1177/07482337231209352.
[2] https://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_152.pdf
Properties of Pyrimidinetetramine sulfate
| Melting point: | >300 °C(lit.) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Heated), Water (Very Slightly, Heated) |
| form | Crystalline Powder |
| color | Ochre to brown |
| Water Solubility | slightly soluble |
| BRN | 3785189 |
| CAS DataBase Reference | 5392-28-9(CAS DataBase Reference) |
| EPA Substance Registry System | Pyrimidinetetramine, sulfate (1:1) (5392-28-9) |
Safety information for Pyrimidinetetramine sulfate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Pyrimidinetetramine sulfate
| InChIKey | MQEFDQWUCTUJCP-UHFFFAOYSA-N |
Pyrimidinetetramine sulfate manufacturer
ALS India Life Sciences Pvt. Ltd
3Y
Phone:+91-8977036378
Whatsapp: +91 8008166674
product: 5392-28-9 2,4,5,6-Tetraaminopyrimidine sulfate 99.30%
ASM Organics
Andhra Pradesh
Phone:91-9866122393
Whatsapp: 91-9866122393
product: 2,4,5,6-Tetraamino pyrimidine sulfate
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