Pseudocoptisine chloride
- CAS NO.：30044-78-1
- Empirical Formula: C19H14ClNO4
- Molecular Weight: 355.77
- MDL number: MFCD33548929
- Update Date: 2026-07-27 17:00:41
What is Pseudocoptisine chloride?
Biological Activity
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects.
in vitro
Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells.
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions.
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells.
in vivo
The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, ip) are examined. Pseudocoptisine (2.0 mg/kg, po) significantly reverses cognitive impairments in mice by passive avoidance test.
Properties of Pseudocoptisine chloride
| storage temp. | Store at -20°C |
| form | Solid |
| color | Yellow to brown |
Safety information for Pseudocoptisine chloride
Computed Descriptors for Pseudocoptisine chloride
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