PSB CB5
- CAS NO.：1627710-30-8
- Empirical Formula: C20H17ClN2O2S
- Molecular Weight: 384.88
- Update Date: 2026-04-22 18:57:36
What is PSB CB5?
Description
PSB-CB5 (1627710-30-8) is a potent and selective GPR18 antagonist (IC50?= 0.279 μM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2.1? Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of human spermatozoa.2
Storage
Store at -20°C
References
1) Rempel?et al. (2014),?Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55; Med. Chem. Comm., 5?632 2) Flegel?et al.?(2016),?Characterization of Non-Olfactory GPCRs in Human Sperm With a Focus on GPR18; Sci. Rep.,?6?32255
Properties of PSB CB5
| Boiling point: | 549.9±60.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) |
| pka | -1.84±0.20(Predicted) |
| form | solid |
| color | Pale yellow |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for PSB CB5
Computed Descriptors for PSB CB5
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