PROTRIPTYLINE HYDROCHLORIDE
Synonym(s):N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine hydrochloride
- CAS NO.：1225-55-4
- Empirical Formula: C19H22ClN
- Molecular Weight: 299.84
- MDL number: MFCD00072057
- EINECS: 214-956-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-03 11:24:09
What is PROTRIPTYLINE HYDROCHLORIDE?
The Uses of PROTRIPTYLINE HYDROCHLORIDE
Monoamine reuptake inhibitor; tricyclic antidepressant.
What are the applications of Application
Protriptyline hydrochloride is A norepinephrine uptake blocker
brand name
Vivactil (Odyssey).
General Description
Protriptyline hydrochloride, N-methyl-5H-dibenzo[a,d]-cycloheptene-5-propylamine hydrochloride, 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene hydrochloride(Vivactil), like the other compounds under consideration, isan effective antidepressant. The basis for its chemical namingcan be seen by consulting the naming and the structureof imipramine. Protriptyline is a structural isomer of nortriptyline.Inactivation can be expected to involve the relativelylocalized double bond. Because it is a monomethylcompound, its sedative potential is low.
Biochem/physiol Actions
Norepinephrine uptake blocker.
Properties of PROTRIPTYLINE HYDROCHLORIDE
| Melting point: | 169-171° |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: soluble50mg/mL |
| form | powder |
| pka | 8.2(at 25℃) |
| color | white to off-white |
| Stability: | Hygroscopic |
Safety information for PROTRIPTYLINE HYDROCHLORIDE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PROTRIPTYLINE HYDROCHLORIDE
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