Protopine
Synonym(s):4,6,7,14-Tetrahydro-5-methylbis[1,3]benzodioxolo[4,5-c:5′,6′-g]azecin-13(5H)-one
- CAS NO.：130-86-9
- Empirical Formula: C20H19NO5
- Molecular Weight: 353.37
- MDL number: MFCD00022322
- EINECS: 204-999-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-17 09:03:53
What is Protopine?
Chemical properties
Off-White Solid
The Uses of Protopine
Protopine is a Ca2+ channel blocker and antiplatelet agent. Immunomodulator
Definition
ChEBI: A dibenzazecine alkaloid isolated from Fumaria vaillantii.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Purification Methods
It crystallises from EtOH/CHCl3. The picrate has m ~240o(dec). [Beilstein 27 H 558, 17 I 568, 17 II 620, 17 III/IV 6881.]
Properties of Protopine
| Melting point: | 203-205?C |
| Boiling point: | 486.8°C (rough estimate) |
| Density | 1.399 (calc) |
| refractive index | 1.5800 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| Water Solubility | Insoluble in water |
| solubility | DMSO : 12.5 mg/mL (35.37 mM; Need ultrasonic) |
| form | powder to crystal |
| pka | 7.86±0.20(Predicted) |
| color | White to Light gray to Light yellow |
| NIST Chemistry Reference | Protopine(130-86-9) |
Safety information for Protopine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P501:Dispose of contents/container to..… |
Computed Descriptors for Protopine
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