PROTHROMBIN
Synonym(s):Coagulation Factor II;Prothrombin, Human Plasma
- CAS NO.：9001-26-7
- Molecular Weight: 0
- MDL number: MFCD00148143
- EINECS: 232-592-3
- Update Date: 2026-05-28 01:25:20
What is PROTHROMBIN?
Definition
The precursor of the enzyme thrombin, a proteinaceous component of blood plasma that is converted into thrombin by the blood- clotting mechanism when activated at the site of an open wound.
Purification Methods
Prothrombin is purified by two absorptions on a barium citrate adsorbent, followed by decomposition of the adsorbents with a weak carboxylic cation-exchanger (Amberlite IRF-97), isoelectric precipitation (pH 4.7-4.9) and further purification by chromatography on Sephadex G-200 or IRC-50. Finally it is recrystallised from a 1% solution adjusted to pH 6.0-7.0 and partial lyophilisation to ca 1/5 to 1/10th volume and set aside at 2-5o to crystallise. Occasionally seeding is required. [Miller Biochemical Preparations 13 49 1971.]
Properties of PROTHROMBIN
| storage temp. | −20°C |
| form | lyophilized powder |
Safety information for PROTHROMBIN
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for PROTHROMBIN
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