PROTAC PARP1 degrader
- CAS NO.：2369022-68-2
- Empirical Formula: C58H63Cl2N11O10
- Molecular Weight: 1145.09
- MDL number: MFCD32705102
- Update Date: 2025-08-21 22:16:43
What is PROTAC PARP1 degrader?
Biological Activity
PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.
References
[1]. Zhao Q, et al. Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule. Chem Commun (Camb). 2019 Jan 2;55(3):369-372.
Properties of PROTAC PARP1 degrader
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| form | Solid |
| pka | 14.32±0.46(Predicted) |
| color | White to off-white |
Safety information for PROTAC PARP1 degrader
Computed Descriptors for PROTAC PARP1 degrader
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