PROTAC KRASG12C Degrader-LC-2
- CAS NO.：2502156-03-6
- Empirical Formula: C59H71ClFN11O7S
- Molecular Weight: 1132.78
- MDL number: MFCD32857122
- Update Date: 2025-04-18 09:52:45
What is PROTAC KRASG12C Degrader-LC-2?
Description
LC-2 is a von Hippel-Lindau-based PROTAC which can degrade endogenous KRAS G12C. It covalently binds KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterzygous KRAS G12C cell lines.
Storage
Store at -20°C
Properties of PROTAC KRASG12C Degrader-LC-2
| Density | 1.297±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 50 mg/mL (44.14 mM; ultrasonic and warming and heat to 80°C) |
| form | Solid |
| pka | 14.07±0.40(Predicted) |
| color | Off-white to brown |
Safety information for PROTAC KRASG12C Degrader-LC-2
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PROTAC KRASG12C Degrader-LC-2
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