proquazone
- CAS NO.：22760-18-5
- Empirical Formula: C18H18N2O
- Molecular Weight: 278.35
- MDL number: MFCD00866169
- EINECS: 245-203-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 16:31:51
What is proquazone ?
The Uses of proquazone
Proquazone is a non-steroidal anti-inflammatory drug.
The Uses of proquazone
Anti-inflammatory.
Definition
ChEBI: Proquazone is a member of pyrimidines.
brand name
Arthrex (Novartis), Biarison (Swiss-Pharma, Egypt; Biochemie, Austria; ICN Alkaloida, Hungary; Sandoz, Finland, Turkey).
Clinical Use
Proquazone has been used successfully to treat rheumatoid polyarthritis. At 900 mg/d it is comparable in effect to 150 mg/d of indomethacin. Gastrointestinal disturbances are the principal adverse effects observed with its use.
Synthesis
Synthesis: proquazone is prepared by the
alkylation of 2-amino-4-methylbenzophenone
with 2-iodopropane in the presence of
sodium carbonate to give 4-methyl-2-[(1-
methylethyl)amino]benzophenone, which is
condensed with urethane in the presence of
zinc chloride at 190 ?C.
Properties of proquazone
| Melting point: | 137-138° |
| Boiling point: | 436.12°C (rough estimate) |
| Density | 1.1707 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| pka | 0.74±0.20(Predicted) |
Safety information for proquazone
Computed Descriptors for proquazone
New Products
3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-Boc-3-(cyanomethyl)azetidine Dimedone 1-N-Boc-3-(aminoethyl)azetidine N-BOC-piperidine-4-carboxylic acid 4,6-Dichlororesorcinol 5-Amino-2-Bromo-3-Chloropyridine 2-Picolinic acid N-oxide 4-Butyl Resorcinol 2-Bromo-5-Chloropyridine 5-Bromo-2-Hydroxy-3-Nitro Pyridine 2-Amino-4-phenyl-thiazole N-(4-Bromophenyl)-2-chloroacetamide TRIFLOURO ACETICACID-D METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3Related products of tetrahydrofuran
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