Propylphosphonic anhydride

Description

Propylphosphonic anhydride (T3P) is a highly reactive n-propyl phosphonic acid cyclic anhydride, generally used as a coupling agent and water scavenger with low toxicity and low allergenic potential. T3P has been demonstrated to be an efficient and mild reagent for the one-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.

Chemical properties

Propylphosphonic anhydride is a clear light yellow solution. T3P is typically sold as a 50% solution in a solvent (ex. EtOAc or DMF).

The Uses of Propylphosphonic anhydride

Propylphosphonic anhydride may be used in the following studies:

• As coupling agent for the synthesis of bispyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.
• Microwave-assissted Fischer indolization of arylhydrazines.
• As acid activating agent for the direct synthesis of acid azides from carboxylic acids.
• One-pot synthesis of coumarins.
• Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.
• One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.
• Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.

General Description

Propylphosphonic anhydride (T3P) is a reactive n-propyl phosphonic acid cyclic anhydride. It is a mild and low toxic coupling agent used in peptide synthesis. T3P also acts as a promoter and water scavenger in the Friedl?nder annulation reaction. It participates in the conversion of carboxylic acids and amides into nitriles, formation of Weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols and C-C coupling reactions. T3P delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products and hence gives high purity and yield of the product.

Flammability and Explosibility

Not classified