Propargyl-succinimidyl-ester
Synonym(s):2,5-Dioxopyrrolidin-1-yl 3-(prop-2-ynyloxy)propanoate;3-(2-Propyn-1-yloxy)propanoic acid 2,5-dioxo-1-pyrrolidinyl ester;Alkyne-NHS ester;Propargyl-succinimidyl-ester
- CAS NO.：1174157-65-3
- Empirical Formula: C10H11NO5
- Molecular Weight: 225.2
- MDL number: MFCD13184973
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-14 15:25:29
What is Propargyl-succinimidyl-ester?
Description
Propargyl-PEG1-NHS ester is an amine reactive reagent that can be used for derivatizing peptides, antibodies, amine coated surfaces etc. The alkyne group reacts with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions.
The Uses of Propargyl-succinimidyl-ester
N-Succinimidyl 3-(propargyloxy)propionate is an acetylene-containing reagent with NHS ester functionality for reaction with amines.
The Uses of Propargyl-succinimidyl-ester
Propargyl-N-hydroxysuccinimidyl ester may be used as a tool for identifying nucleophilic ligandable hotspots by chemoproteomic approaches.
What are the applications of Application
Propargyl-succinimidyl-ester is an amine reactive crosslinker for incorporation of a terminal alkyne
Properties of Propargyl-succinimidyl-ester
| Melting point: | 36-41°C |
| Boiling point: | 351.2±48.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO, DCM, DMF |
| form | Solid |
| color | Gray |
| Water Solubility | Slightly soluble in water. |
Safety information for Propargyl-succinimidyl-ester
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Propargyl-succinimidyl-ester
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