Propargyl-PEG2-acid
- CAS NO.：1859379-85-3
- Empirical Formula: C8H12O4
- Molecular Weight: 172.18
- MDL number: MFCD29764323
- Update Date: 2026-03-13 09:27:42
What is Propargyl-PEG2-acid?
Description
Propargyl-PEG2-acid is a linker consisting of propargyl and carboxylic acid functional groups. In the presence of activators (e.g. EDC, or HATU), the carboxylic acid reacts with primary amine to form a stable amide bond. The propargyl group reacts with azide group in biomolecules to yield a stable triazole linkage.
The Uses of Propargyl-PEG2-acid
Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Properties of Propargyl-PEG2-acid
| storage temp. | -20°C |
| solubility | DMSO: 250 mg/mL (1451.97 mM) |
| form | Liquid |
| color | Colorless to light yellow |
Safety information for Propargyl-PEG2-acid
Computed Descriptors for Propargyl-PEG2-acid
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