Propargyl-PEG5-amine

CAS NO.：1589522-46-2
Empirical Formula: C13H25NO5
Molecular Weight: 275.34
MDL number: MFCD27977505
Update Date: 2026-05-28 02:24:53

What is Propargyl-PEG5-amine?

Description

Propargyl-PEG5-amine is a propargyl linker that is commonly used as a Click Chemistry reagent for copper-catalyzed reactions with azides. The amine moiety reacts with carboxylic acids, activated NHS esters and other carbonyl compounds. The PEG spacer helps improve the water solubility of the molecule in aqueous media.

Biological Activity

Propargyl-PEG5-amine is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Properties of Propargyl-PEG5-amine

Boiling point:	360.4±37.0 °C(Predicted)
Density	1.049±0.06 g/cm3(Predicted)
solubility	DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)
pka	8.74±0.10(Predicted)
form	Liquid
color	Colorless to light yellow

Safety information for Propargyl-PEG5-amine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P330:Rinse mouth. P363:Wash contaminated clothing before reuse. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P501:Dispose of contents/container to..…