Propargyl-PEG4-thiol
- CAS NO.：1347750-80-4
- Empirical Formula: C11H20O4S
- Molecular Weight: 248.3391
- MDL number: MFCD29764343
- Update Date: 2026-03-18 11:52:23
What is Propargyl-PEG4-thiol?
Description
Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.
Biological Activity
Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of Propargyl-PEG4-thiol
| Boiling point: | 332.9±37.0 °C(Predicted) |
| Density | 1.064±0.06 g/cm3(Predicted) |
| solubility | Soluble in DMSO, DCM, DMF |
| pka | 9?+-.0.10(Predicted) |
Safety information for Propargyl-PEG4-thiol
Computed Descriptors for Propargyl-PEG4-thiol
New Products
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