Propargyl-PEG6-acid
Synonym(s):4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid;Propargyl-PEG6-CH2CO2H
- CAS NO.：1951438-84-8
- Empirical Formula: C16H28O8
- Molecular Weight: 348.39
- MDL number: MFCD28950778
- Update Date: 2026-04-21 10:31:43
What is Propargyl-PEG6-acid?
Description
Propargyl-PEG6-acid comprises propargyl and carboxylic acid functional groups. The acid group reacts with primary amines in the presence of activators (e.g. EDC, or HATU).The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The molecule has good solubility in aqueous environment.
The Uses of Propargyl-PEG6-acid
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Properties of Propargyl-PEG6-acid
| Boiling point: | 462.8±45.0 °C(Predicted) |
| Density | 1.126±0.06 g/cm3(Predicted) |
| refractive index | n/D 1.469 |
| storage temp. | -20°C |
| solubility | Soluble in Water |
| form | liquid |
| pka | 4.28±0.10(Predicted) |
| color | Colorless to light yellow |
Safety information for Propargyl-PEG6-acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Propargyl-PEG6-acid
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