Propargyl-PEG6-acid

Synonym(s):4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid;Propargyl-PEG6-CH2CO2H

CAS NO.：1951438-84-8
Empirical Formula: C16H28O8
Molecular Weight: 348.39
MDL number: MFCD28950778
Update Date: 2025-11-25 17:52:38

What is Propargyl-PEG6-acid?

Description

Propargyl-PEG6-acid comprises propargyl and carboxylic acid functional groups. The acid group reacts with primary amines in the presence of activators (e.g. EDC, or HATU).The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The molecule has good solubility in aqueous environment.

The Uses of Propargyl-PEG6-acid

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Properties of Propargyl-PEG6-acid

Boiling point:	462.8±45.0 °C(Predicted)
Density	1.126±0.06 g/cm3(Predicted)
refractive index	n/D 1.469
storage temp.	-20°C
solubility	Soluble in Water
form	liquid
pka	4.28±0.10(Predicted)
color	Colorless to light yellow

Safety information for Propargyl-PEG6-acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.