Posatirelin
- CAS NO.：78664-73-0
- Empirical Formula: C17H28N4O4
- Molecular Weight: 352.432
- MDL number: MFCD00865152
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-14 09:55:04
What is Posatirelin?
Description
Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic decit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a signicant improvement in intellectual performance, orientation, motivation and memory as compared to controls. e drug was well tolerated.
The Uses of Posatirelin
Posatirelin is a thyrotropin-releasing hormone analogue, used in the treatment of seizures and some neurodegenerative disease such as vascular dementia and Parkinson''s disease.
Definition
ChEBI: Posatirelin is an oligopeptide.
Properties of Posatirelin
| Melting point: | 214-216° |
| alpha | D25 -80.2° (c = 1 in acetic acid) |
| Boiling point: | 739.6±60.0 °C(Predicted) |
| Density | 1.214±0.06 g/cm3(Predicted) |
| pka | 13.56±0.20(Predicted) |
Safety information for Posatirelin
Computed Descriptors for Posatirelin
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