POPSO
Synonym(s):Piperazine-1,4-bis(2-hydroxypropanesulfonic acid) dihydrate;Piperazine-N,N′-bis(2-hydroxypropanesulfonic acid)
- CAS NO.：68189-43-5
- Empirical Formula: C10H22N2O8S2
- Molecular Weight: 362.42
- MDL number: MFCD00038350
- EINECS: 269-199-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-25 17:39:00
What is POPSO?
Description
POPSO (Piperazine-1,4-bis(2-hydroxypropanesulfonic Acid) Dihydrate) is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC50 value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5.
Chemical properties
white powder
Properties of POPSO
| Melting point: | 320°C |
| Density | 1.578±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 1 M NaOH: 0.1 M, clear, colorless |
| form | Solid |
| color | White powder |
| pka | 7.8(at 25℃) |
| PH Range | 7.2 - 8.5 |
| BRN | 842252 |
| InChI | InChI=1S/C10H22N2O8S2.2H2O/c13-9(7-21(15,16)17)5-11-1-2-12(4-3-11)6-10(14)8-22(18,19)20;;/h9-10,13-14H,1-8H2,(H,15,16,17)(H,18,19,20);2*1H2 |
| CAS DataBase Reference | 68189-43-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1,4-Piperazinedipropanesulfonic acid, .beta.,.beta.'-dihydroxy- (68189-43-5) |
Safety information for POPSO
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for POPSO
| InChIKey | PDSOJBZKKTTWHS-UHFFFAOYSA-N |
| SMILES | S(=O)(=O)(O)CC(O)CN1CCN(CC(O)CS(=O)(=O)O)CC1.O.O |
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