Pomalidomide-PEG4-NH2 hydrochloride

Synonym(s):14-Amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecanamide hydrochloride;Crosslinker−E3 Ligase ligand conjugate;Protein degrader building block for PROTAC research;Template for synthesis of targeted protein degrader

CAS NO.：2331259-45-9
Molecular Weight: 542.97
Update Date: 2026-05-27 22:56:22

Pomalidomide-PEG4-NH2 hydrochloride Structural

What is Pomalidomide-PEG4-NH2 hydrochloride?

The Uses of Pomalidomide-PEG4-NH2 hydrochloride

Protein degrader builiding block Pomalidomide-PEG₄-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Properties of Pomalidomide-PEG4-NH2 hydrochloride

storage temp.	2-8°C
solubility	DMSO : 250 mg/mL (460.43 mM; Need ultrasonic)
form	Solid
color	White to yellow

Safety information for Pomalidomide-PEG4-NH2 hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Pomalidomide-PEG4-NH2 hydrochloride

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