Polyhexamethyleneguanidine phosphate
- CAS NO.：89697-78-9
- Empirical Formula: C21H45N9X2.3H3O4P
- Molecular Weight: 717.631
- MDL number: MFCD01742719
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-29 17:05:30
What is Polyhexamethyleneguanidine phosphate?
The Uses of Polyhexamethyleneguanidine phosphate
Polyhexamethyleneguanidine phosphate (PHMG-P) has been widely used as a disinfectant because of its strong bactericidal activity and low toxicity.
Toxicity evaluation
Administration of PHMG-P induced proinflammatory cytokines elevation and infiltration of immune cells into the lungs. Histopathological analysis revealed a dose-dependent exacerbation of both inflammation and pulmonary fibrosis on day 14. PHMG-P also decreased the total cell number and the CD4+/CD8+ cell ratio in the thymus, with the histopathological examination indicating severe reduction of cortex and medulla. The mRNA levels of biomarkers associated with T cell development also decreased markedly. These findings suggest that exposure of lung tissue to PHMG-P leads to pulmonary inflammation and fibrosis as well as thymic atrophy.
Safety information for Polyhexamethyleneguanidine phosphate
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