PL017
- CAS NO.：83397-56-2
- Empirical Formula: C29H37N5O5
- Molecular Weight: 535.63
- MDL number: MFCD00135717
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-17 18:22:24
What is PL017?
Biological Activity
PL-017 is a potent and selective μ opioid receptor agonist with IC50 of 5.5 nM for 125I-FK 33,824 binding to the μ site. PL-017 produces durable and reversible analgesia in rats.
in vitro
PL-017 has an IC 50 of 10000 nM for 125 I-DADLE binding to δ site.
in vivo
PL-017 (0.22, 0.45, 0.9 nmol/rat; icv) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g.
Properties of PL017
| Boiling point: | 878.5±65.0 °C(Predicted) |
| Density | 1.313±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| form | Powder |
| pka | 9.86±0.15(Predicted) |
| Water Solubility | Soluble to 1 mg/ml in water |
Safety information for PL017
Computed Descriptors for PL017
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