PL017
- CAS NO.：83397-56-2
- Empirical Formula: C29H37N5O5
- Molecular Weight: 535.63
- MDL number: MFCD00135717
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:28
What is PL017?
Biological Activity
PL-017 is a potent and selective μ opioid receptor agonist with IC50 of 5.5 nM for 125I-FK 33,824 binding to the μ site. PL-017 produces durable and reversible analgesia in rats.
in vitro
PL-017 has an IC 50 of 10000 nM for 125 I-DADLE binding to δ site.
in vivo
PL-017 (0.22, 0.45, 0.9 nmol/rat; icv) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g.
Properties of PL017
| Boiling point: | 878.5±65.0 °C(Predicted) |
| Density | 1.313±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| form | Powder |
| pka | 9.86±0.15(Predicted) |
| Water Solubility | Soluble to 1 mg/ml in water |
Safety information for PL017
Computed Descriptors for PL017
New Products
Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Cis-Tosylate Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) BOC Piperazine 1-Benzhydrylazetane-3-carbonitrile 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione (±)-amino(2-fluorophenyl)acetic acid 2-(2-Chlorophenyl)glycine AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2'-Fluoroacetophenone METHANOL-D1(OD) TERTIARY BUTANOL-D9 N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D TOLUENE-D3 Trans,trans muconic acid HC Blue-16 4-Amino-2-chloro-6,7-dimethoxyquinazoline Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate 2,3-Dimethoxypyridine 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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