Piretanide
Synonym(s):4-Phenoxy-3-(1-pyrrolidinyl)-5-sulfamoylbenzoic acid;Piretanide
- CAS NO.：55837-27-9
- Empirical Formula: C17H18N2O5S
- Molecular Weight: 362.4
- MDL number: MFCD00867334
- EINECS: 259-852-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 16:31:51
What is Piretanide?
Chemical properties
Pale Yellow Solid
Originator
Arelix ,Hoechst, Italy ,1980
The Uses of Piretanide
High-ceiling loop diuretic; structurally related to Bumetanide (B689550). Diuretic.
Background
Piretanide (INN, trade names Arelix, Eurelix, Tauliz) has been synthesized in 1973 at Hoechst AG (Germany) as a loop diuretic compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other aromatically bonded functional groups.
Definition
ChEBI: Piretanide is an aromatic ether.
brand name
Arlix (Hoechst-Roussel).
Therapeutic Function
Diuretic
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Used as a diuretic agent. When heated to decomposition it emits very toxic fumes of SOx an
Metabolism
Not Available
Properties of Piretanide
| Melting point: | 225-227° |
| Boiling point: | 253°C (rough estimate) |
| Density | 1.3049 (rough estimate) |
| refractive index | 1.6510 (estimate) |
| storage temp. | 2-8°C |
| solubility | Very slightly soluble in water, sparingly soluble in anhydrous ethanol. It shows polymorphism (5.9). |
| form | neat |
| pka | 10.22±0.60(Predicted) |
| form | Solid |
| color | Pale-yellow platelets from MeOH (aq) |
| CAS DataBase Reference | 55837-27-9(CAS DataBase Reference) |
Safety information for Piretanide
Computed Descriptors for Piretanide
New Products
2-Amino-5-bromo- benzoic acid Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Cis-Tosylate Dibenzo[b,f][1,4]thiazepin-11(10H)-one BOC Piperazine N-Methyl-2-amino-2-methylpropionamide 4-(FMOC-AMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 1-Aminocyclobutanecarboxylic Acid Hydrochloride 3-Oxocyclobutanecarboxylic acid AMINO(2-BROMOPHENYL)ACETIC ACID 6-BROMOTETRAZOLO[1,5-A]PYRIDINE 4-Amino-2-chloro-6,7-dimethoxyquinazoline 2,3-Dimethoxypyridine 2,6-bis(bromomethyl)pyridine tert-Butyl 4-mercaptopiperidine-1-carboxylate 4'-(Methylmercapto)-acetophrnonone 1-Benzhydrylazetidin-3-ol-Hcl 1-(3-Chlorophenyl)piperazine hydrochloride Enzyme Breaker for Coal Bed Methane Slickwaterr Gas Well Guar Gum Enzyme Breaker Enzyme Breaker for Conventional Slickwater Fracturing Conventional Fracturing Guar Gum Enzyme Breaker Coalbed Methane Guar Gum Enzyme BreakerRelated products of tetrahydrofuran
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