pipradrol hydrochloride

Description

Pipradrol is a mild stimulant containing a piperidine ring. Once used as a treatment for obesity and dementia, pipradrol is now regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

Chemical properties

White Solid

Originator

Alertonic ,Adcock Ingram Ltd.

The Uses of pipradrol hydrochloride

Controlled substance (stimulant). CNS stimulant

Definition

ChEBI: Pipradrol hydrochloride is a diarylmethane.

Manufacturing Process

A mixture of 48 g (0.167 mole) of α,α-diphenyl-2-pyridinemethanol hydrochloride (Emraert et al., Ber. 72B, 1188 (1939); 74B, 714 (1940), 160 ml of ethanol, and 3 0.5 g of Adams' platinum catalyst was shaken under an initial hydrogen pressure of 60 pounds. The theoretical amount of hydrogen was absorbed in 5 hours. The reaction mixture was refluxed, diluted with enough water to dissolve all the white solid, and filtered hot from the catalyst. The filtrate was cooled and filtered; yield of 38 g of α,α-diphenyl-alpha-(2piperidyl)methanol white product melting at 308-309°C with decomposition.
A mixture of 3.5 grams (0.013 mole) of the above α,α-diphenyl-alpha-(2piperidyl)methanol, 4 g (0.05 mole) of formaldehyde (37%), and 6 grams (0.1 mole) of formic acid was refluxed for 2 days. The reaction mixture was treated with 1.3 g (0.013 mole) of conc. hydrochloric acid and vacuum distilled on the steam bath. The residue was recrystallized from butanone to give the α,αdiphenyl-alpha-(2-piperidyl)methanol hydrochloride which melted at 228229°C (dec.).

brand name

Meratran (Marion Merrell Dow).

Therapeutic Function

Central stimulant

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of HCl and NOx.