Piperidine hydrochloride
- CAS NO.：6091-44-7
- Empirical Formula: C5H11N.ClH
- Molecular Weight: 121.61
- MDL number: MFCD00012770
- EINECS: 228-033-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is Piperidine hydrochloride?
Chemical properties
WHITE FINE CRYSTALLINE POWDER
The Uses of Piperidine hydrochloride
Piperidine hydrochloride is used an intermediate in the manufacture of active pharmaceutical ingredients like anti Parkinsonan agent Biperiden; anti depressant agent Clocapramine hydrochloride and muscle relaxant tolperisone.
The Uses of Piperidine hydrochloride
Reagent for synthesis of:
- Quinoline selenium compounds
- Peripheral seratonin 5-HT3 receptor ligands
Reactant for synthesis of phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors
Reactant for:
- Mannich reactions
- Asymmetric hydrogenation of quinolines
- Chemoselective reductive amination of carbonyl compounds
Purification Methods
Crystallise the salt from EtOH/diethyl ether in the presence of a small amount of HCl. [Beilstein 20 H 6, 20 II 10, 20 III/IV 295, 20/2 V 13.]
Properties of Piperidine hydrochloride
| Melting point: | 245-248 °C(lit.) |
| Boiling point: | 347.05℃ |
| Density | 1,12 g/cm3 |
| vapor density | 2.94 (vs air) |
| vapor pressure | 63.6 mm Hg ( 37.8 °C) |
| Flash point: | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | >1500g/l |
| form | Solid:crystalline |
| PH | 6-8 (111g/l, H2O, 20℃) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 3611699 |
| CAS DataBase Reference | 6091-44-7(CAS DataBase Reference) |
| EPA Substance Registry System | Piperidine hydrochloride (6091-44-7) |
Safety information for Piperidine hydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for Piperidine hydrochloride
| InChIKey | VEIWYFRREFUNRC-UHFFFAOYSA-N |
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