Picotamide
Synonym(s):4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
- CAS NO.：32828-81-2
- Empirical Formula: C21H20N4O3
- Molecular Weight: 376.41
- MDL number: MFCD00866792
- EINECS: 251-245-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is Picotamide?
Description
Picotamide is an unique antithrombotic agent which acts by selectively inhibiting thromboxane synthesis and blocking platelet thromboxane receptors without affecting prostaglandin synthesis. It is reported to be useful in the treatment of myocardial infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis.
Originator
Manetti-Roberts (Beecham (Italy)
The Uses of Picotamide
Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase. It is used in aptamers for targeting coagulation factor XIII and there used for treatment of thrombosis.
The Uses of Picotamide
Keratolytic.
What are the applications of Application
Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase
Definition
ChEBI: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide is a member of benzamides.
brand name
Plactidil
References
Modesti, et al. (1989), Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide; Eur. J. Pharmacol.. 169 85 Modesti, et al. (1991), Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 inhibitor; Br. J. Pharmacol.. 31 439 Ratti et al. (1998), Picotamide, an antithromboxane agent. Inhibits the migration and proliferation of arterial myocytes; Eur. J. Pharmacol. 355 77
Properties of Picotamide
| Melting point: | 128-131℃ |
| Boiling point: | 668.1±55.0 °C(Predicted) |
| Density | 1.246±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming). |
| form | White solid. |
| pka | 13.31±0.46(Predicted) |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
Safety information for Picotamide
| GHS Hazard Statements |
H303:Acute toxicity,oral |
| Precautionary Statement Codes |
P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P403:Store in a well-ventilated place. |
Computed Descriptors for Picotamide
Picotamide manufacturer
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloropyridazine 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 6-Methyl-2-pyridinemethanol 2-Pyridinecarboxaldehdye tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 1-Indanone 2-Chloromethyl-6-methyl-pyridine 4-Morpholinoaniline Abiraterone Ethyl Ether 1-nitro-3,5-dimethyl adamantine (NMEM) Vardenafil Bis-sulphonamide(Dimer) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneRelated products of tetrahydrofuran
![3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide](https://img.chemicalbook.in/CAS/GIF/860352-01-8.gif)
You may like
-
32828-81-2 Picotamide 98%View Details
32828-81-2 -
Picotamide CAS 32828-81-2View Details
32828-81-2 -
3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2304754-51-4 99%+View Details
2304754-51-4 -
1126-74-5 99%+View Details
1126-74-5 -
2-Fluoro-6-iodobenzoic acid 99%+View Details
111771-08-5 -
120013-39-0 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride 99%+View Details
120013-39-0 -
ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate 313544-31-9 99%+View Details
313544-31-9 -
1-Boc-4-cyanopiperidine 91419-52-2 99%+View Details
91419-52-2