Phthalylglycyl chloride
Synonym(s):1,3-Dioxo-2-isoindolineacetyl chloride;NSC 401729;Phthalylglycine acid chloride
- CAS NO.：6780-38-7
- Empirical Formula: C10H6ClNO3
- Molecular Weight: 223.61
- MDL number: MFCD00192872
- EINECS: 229-840-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-11-18 14:22:45
What is Phthalylglycyl chloride?
Chemical properties
slight yellow to white crystalline powder
The Uses of Phthalylglycyl chloride
Reactant involved in:• ;Synthesis of selenium-containing amino acid analogs with bactericidal and antifungal activity1• ;Photoinduced single electron transfer cyclization for preparation of cyclic peptides2• ;Arndt-Eistert synthesis3• ;Mitsunobu and arbuzov-type multicomponent pathway4• ;Remote C-H bond functionalization5• ;Amido-alkylation for synthesis of benzofuran derivatives6
The Uses of Phthalylglycyl chloride
Phthalylglycyl chloride can be used in the synthesis of N-Phthalimidoacetyl-β-phenylethylamnine.
General Description
Phthalylglycyl chloride can be synthesized via reaction of phthalyl-glycine with thionyl chloride.
Properties of Phthalylglycyl chloride
| Melting point: | 84-85 °C |
| Boiling point: | 190-192 °C(Press: 15 Torr) |
| Density | 1.504±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform, Dichloromethane |
| form | Solid |
| pka | -2.56±0.20(Predicted) |
| color | White |
Safety information for Phthalylglycyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Phthalylglycyl chloride
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