PHENYL-P-BENZOQUINONE

Chemical properties

Yellow-brown chunks and powder

The Uses of PHENYL-P-BENZOQUINONE

Phenylquinone is used for small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity whichrepresents a potential strategy for anticancer therapy.

Synthesis Reference(s)

Journal of the American Chemical Society, 118, p. 2509, 1996 DOI: 10.1021/ja954009q

Safety Profile

Poison by intraperitoneal route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes

Purification Methods

Crystallise the quinone from heptane, pet ether (b 60-70o), *C6H6 (m 113.5-114.5o) or EtOH (m 112-113o) and sublime it in vacuo. [Carlson & Miller J Am Chem Soc 107 479 1985, Beilstein 7 H 740, 7 III 3764.]