PHENAMIL
Synonym(s):3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt
- CAS NO.：2038-35-9
- Empirical Formula: C12H12ClN7O
- Molecular Weight: 305.72
- MDL number: MFCD00210211
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-05 11:31:08
What is PHENAMIL?
The Uses of PHENAMIL
Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte
What are the applications of Application
Phenamil methanesulfonate salt is an amiloride analog that irreversibly blocks amiloride-sensitive Na+ channels.
Definition
ChEBI: Phenylamil is a member of pyrazines and a member of guanidines.
Enzyme inhibitor
This amiloride derivative (FW = 306.73 g/mol; CAS 2038-35-9), also known as 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazine carboxamide, irreversibly inhibits amiloride-sensitive Na+ channels. It is often supplied commercially as the methanesulfonate salt. Na+ channel blockers, such as phenamil and benzamil, are be alsoing explored as a way to counteract the hyperabsorption of NaCl in cystic fibrosis airways. Target(s): diamine oxidase; Na+ channels; and Na+ -driven flagellar motility.
Properties of PHENAMIL
| Melting point: | >181°C (dec.) |
| Density | 1.65±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >15 mg/mL |
| form | solid |
| pka | 8.10±0.46(Predicted) |
| color | yellow |
Safety information for PHENAMIL
Computed Descriptors for PHENAMIL
New Products
DL-beta-(3-Bromophenyl)alanine 1-Aminocyclopentane carbonitrile (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) Benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate Amlodipine EP Impurity-C Budesonide Impurity-K/Budesonide 21-Acetate (Epimers) Gabapentine Impurity 72 Bicalutamide Impurity-B Betahistine EP Impurity C Carbamazepine EP Impurity G 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene 5-Methyl-1,3-benzenediacetonitrile (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 3-Hydroxypropionitrile 4-Bromo Benzylcyanide valeronitrile 3,4 Dimethoxy Benzylcyanide 3-chlorobenzyl cyanide 2-Chloro BenzylcyanideRelated products of tetrahydrofuran
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