PHENAMIL
Synonym(s):3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt
- CAS NO.：2038-35-9
- Empirical Formula: C12H12ClN7O
- Molecular Weight: 305.72
- MDL number: MFCD00210211
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is PHENAMIL?
The Uses of PHENAMIL
Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte
What are the applications of Application
Phenamil methanesulfonate salt is an amiloride analog that irreversibly blocks amiloride-sensitive Na+ channels.
Definition
ChEBI: Phenylamil is a member of pyrazines and a member of guanidines.
Enzyme inhibitor
This amiloride derivative (FW = 306.73 g/mol; CAS 2038-35-9), also known as 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazine carboxamide, irreversibly inhibits amiloride-sensitive Na+ channels. It is often supplied commercially as the methanesulfonate salt. Na+ channel blockers, such as phenamil and benzamil, are be alsoing explored as a way to counteract the hyperabsorption of NaCl in cystic fibrosis airways. Target(s): diamine oxidase; Na+ channels; and Na+ -driven flagellar motility.
Properties of PHENAMIL
| Melting point: | >181°C (dec.) |
| Density | 1.65±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >15 mg/mL |
| form | solid |
| pka | 8.10±0.46(Predicted) |
| color | yellow |
Safety information for PHENAMIL
Computed Descriptors for PHENAMIL
New Products
2-(2-Chlorophenyl)glycine Propiolic Acid 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-Pentadecanol 2,4-Dihydroxybenzaldehyde Dipropyl disulfide Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Obidoxime hydrochloride API 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 2-Pentyn-1-oL 4-NitrobenzotrifluorideRelated products of tetrahydrofuran
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