PHENAMIL
Synonym(s):3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt
- CAS NO.：2038-35-9
- Empirical Formula: C12H12ClN7O
- Molecular Weight: 305.72
- MDL number: MFCD00210211
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 19:39:08
What is PHENAMIL?
The Uses of PHENAMIL
Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte
What are the applications of Application
Phenamil methanesulfonate salt is an amiloride analog that irreversibly blocks amiloride-sensitive Na+ channels.
Definition
ChEBI: Phenylamil is a member of pyrazines and a member of guanidines.
Enzyme inhibitor
This amiloride derivative (FW = 306.73 g/mol; CAS 2038-35-9), also known as 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazine carboxamide, irreversibly inhibits amiloride-sensitive Na+ channels. It is often supplied commercially as the methanesulfonate salt. Na+ channel blockers, such as phenamil and benzamil, are be alsoing explored as a way to counteract the hyperabsorption of NaCl in cystic fibrosis airways. Target(s): diamine oxidase; Na+ channels; and Na+ -driven flagellar motility.
Properties of PHENAMIL
| Melting point: | >181°C (dec.) |
| Density | 1.65±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >15 mg/mL |
| form | solid |
| pka | 8.10±0.46(Predicted) |
| color | yellow |
Safety information for PHENAMIL
Computed Descriptors for PHENAMIL
New Products
Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 2-Bromo-5-hydroxybenzoic acid. 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 4-Fluorophenylglycine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 1-Boc-3-(cyanomethyl)azetidine N-BOC-piperidine-4-carboxylic acid 1-Benzhydrylazetane-3-carbonitrile 5-Amino-2-Hydroxypyridine 2-Amino-5-Iodopyridine 2-BROMOACETYL BROMIDE-D2 METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3 6-Chloro-pyrimidine-2,4-diamine 3-Oxide 1-Acetyl-4-(4-hydroxyphenyl)piperazine 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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