PHENAMIL METHANESULFONATE
- CAS NO.：1161-94-0
- Empirical Formula: C13H16ClN7O4S
- Molecular Weight: 401.8
- MDL number: MFCD00274070
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:14:21
What is PHENAMIL METHANESULFONATE?
Chemical properties
off-white to yellow solid
The Uses of PHENAMIL METHANESULFONATE
Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte
The Uses of PHENAMIL METHANESULFONATE
Phenamil methanesulfonate salt has been used:
- to stimulate adipocyte differentiation in 3T3 cells
- to test its effect on lateral flagella expression in Vibrio shilonii
- in nanoparticle preparation to test its effect on osteo/odontoblastic differentiation
General Description
Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC).
Biochem/physiol Actions
Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells.
Storage
Store at +4°C
Properties of PHENAMIL METHANESULFONATE
| storage temp. | 2-8°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.5mg/mL |
| form | solid |
| color | yellow |
| CAS DataBase Reference | 1161-94-0 |
Safety information for PHENAMIL METHANESULFONATE
Computed Descriptors for PHENAMIL METHANESULFONATE
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
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