PF-622
- CAS NO.：898235-65-9
- Empirical Formula: C21H22N4O
- Molecular Weight: 346.43
- MDL number: MFCD10567108
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-06 15:14:14
What is PF-622?
Description
PF-622 (898235-65-9) is a potent and selective irreversible FAAH inhibitor. Covalently modifies active site-serine (IC50=33 nM). Completely selective for FAAH relative to other mammalian serine hydrolases. Cell permeable
What are the applications of Application
PF-622 is a novel, potent and selective inhibitor of FAAH (fatty acid amide hydrolase)
in vitro
pf-622 inhibited the activity of faah in a time-dependent manner with the ic50 values of 0.99 and 0.033 μm in human recombinant faah for 5 and 60 minutes, respectively [1]. in various human and murine tissue proteome samples, pf-622 showed highly selectivity for faah in relative to other serine hydrolases, showing no discernable off-site activity up to 500 μm [1]. pf-622 at 1 μm decreased il-2 production in both healthy subjects and in hcv patients [2].
References
1) Ahn et al. (2007), Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity; Biochemistry, 46 13019
Properties of PF-622
| storage temp. | RT |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml). |
| form | Off-white solid. |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
Safety information for PF-622
Computed Descriptors for PF-622
New Products
3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-Boc-3-(cyanomethyl)azetidine Dimedone 1-N-Boc-3-(aminoethyl)azetidine N-BOC-piperidine-4-carboxylic acid 4,6-Dichlororesorcinol 5-Amino-2-Bromo-3-Chloropyridine 2-Picolinic acid N-oxide 4-Butyl Resorcinol 2-Bromo-5-Chloropyridine 5-Bromo-2-Hydroxy-3-Nitro Pyridine 2-Amino-4-phenyl-thiazole N-(4-Bromophenyl)-2-chloroacetamide TRIFLOURO ACETICACID-D METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3Related products of tetrahydrofuran
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