PF-06471553
- CAS NO.：1808094-07-6
- Empirical Formula: C23H25N5O4S
- Molecular Weight: 467.54
- MDL number: MFCD31657365
- Update Date: 2026-04-22 18:57:36
What is PF-06471553?
Description
PF-06471553 is a potent and selective Monoacylglycerol acyltransferase 3 (MGAT3) inhibitor. PF-06471553 selectively inhibits MGAT3 with high in vitro potency and cell efficacy. In the presence of a combination of diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2) inhibitors, an oral administration of PF-06471553 exhibited inhibition of the incorporation of deuterium-labeled glycerol into TAG in mouse model. Inhibition of triacylglycerol (TAG) biosynthetic enzymes has been suggested as a promising strategy to treat insulin resistance, diabetes, dyslipidemia, and hepatic steatosis.
Properties of PF-06471553
| Boiling point: | 728.7±70.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 150 mg/mL (320.83 mM) |
| form | Solid |
| pka | 6.75±0.20(Predicted) |
| color | White to off-white |
Safety information for PF-06471553
Computed Descriptors for PF-06471553
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