PF-06446846 HYDROCHLORIDE
Synonym(s):N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
- CAS NO.：1632250-50-0
- Empirical Formula: C22H21Cl2N7O
- Molecular Weight: 470.36
- Update Date: 2026-04-22 18:57:36
What is PF-06446846 HYDROCHLORIDE?
Biological Activity
PF-06446846 hydrochloride is an orally active, highly selective translation inhibitor of the proprotein convertase subtilisin/kexin type 9 (PCSK9). It inhibits PCSK9 by inducing ribosome parking around codon 34.
in vitro
PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC 50 of 0.3 μM.
in vivo
PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.
| Animal Model: | Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing) |
| Dosage: | 5, 15, and 50 mg/kg |
| Administration: | Oral gavage; daily for 14 days |
| Result: | Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels. |
Properties of PF-06446846 HYDROCHLORIDE
| storage temp. | room temp |
| solubility | DMSO : 250 mg/mL (531.52 mM) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -60 to -50°, c = 1 in methanol |
Safety information for PF-06446846 HYDROCHLORIDE
Computed Descriptors for PF-06446846 HYDROCHLORIDE
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloropyridazine 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 6-Methyl-2-pyridinemethanol 2-Pyridinecarboxaldehdye tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 1-Indanone 2-Chloromethyl-6-methyl-pyridine 4-Morpholinoaniline Abiraterone Ethyl Ether 1-nitro-3,5-dimethyl adamantine (NMEM) Vardenafil Bis-sulphonamide(Dimer) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneRelated products of tetrahydrofuran
![4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide](https://img.chemicalbook.in/CAS/GIF/947303-87-9.gif)
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