(PENTAFLUOROETHYL)TRIMETHYLSILANE

Synonym(s):(Pentafluoroethyl)trimethylsilane

CAS NO.：124898-13-1
Empirical Formula: C5H9F5Si
Molecular Weight: 192.2
MDL number: MFCD04116436
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:24:48

(PENTAFLUOROETHYL)TRIMETHYLSILANE Structural

What is (PENTAFLUOROETHYL)TRIMETHYLSILANE?

The Uses of (PENTAFLUOROETHYL)TRIMETHYLSILANE

(Pentafluoroethyl)trimethylsilane acts as a silicon-based fluorinating reagent for trifluoromethylation of carbonyls and ethylene diamines. It is also employed as a precursor for metal-mediated trifluoromethylation of aromatic, heteroaromatic and vinyl substrates.

The Uses of (PENTAFLUOROETHYL)TRIMETHYLSILANE

Silicon-based fluorinating reagents for the efficient trifluoromethylation of carbonyls and ethylene diamines. Precursors used for metal-mediated trifluoromethylation of aromatic, heteroaromatic, vinyl substrates, etc.

The Uses of (PENTAFLUOROETHYL)TRIMETHYLSILANE

Trimethylpentafluoroethylsilane ((Pentafluoroethyl)trimethylsilane) may be used as a perfluoroalkylating reagent for the synthesis of the following quinoline derivatives:

5-bromo-2-(perfluoroethyl)quinoline
8-methoxy-2-(perfluoroethyl)quinoline
1-(perfluoroethyl)isoquinoline
8-(tert-butoxy)-5,7-dichloro-2-(perfluoroethyl)quinolone

It may also be used in the synthesis of pentafluoroethylcyclohexanes.

General Description

Trimethylpentafluoroethylsilane ((Pentafluoroethyl)trimethylsilane) is a perfluoroalkylsilane. Alkyl triflates undergo nucleophilic pentafluoroethylation with trimethylpentafluoroethylsilane to form the corresponding pentafluoroethylated alkanes.

Properties of (PENTAFLUOROETHYL)TRIMETHYLSILANE

Boiling point:	60 °C
Density	1.095 g/mL
refractive index	1.3270
Flash point:	-17℃
solubility	Miscible with tetrahydrofuran.
form	liquid
color	colorless
Specific Gravity	1.05
Hydrolytic Sensitivity	4: no reaction with water under neutral conditions
Sensitive	Moisture Sensitive
Stability:	Moisture Sensitive, Volatile
CAS DataBase Reference	124898-13-1(CAS DataBase Reference)
EPA Substance Registry System	(Pentafluoroethyl)trimethylsilane (124898-13-1)

Safety information for (PENTAFLUOROETHYL)TRIMETHYLSILANE

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.