Pentafluoro-1-propanol

Chemical properties

clear colorless to slightly yellow liquid

The Uses of Pentafluoro-1-propanol

2,2,3,3,3-Pentafluoro-1-Propanol is a useful reagent for the preparation of (oxoindolinyl)ethers/benzoates via photochemical O-H functionalization reactions of cyclic diazoamides.

The Uses of Pentafluoro-1-propanol

2,2,3,3,3-Pentafluoro-1-propanol has been used:

• as derivatization reagent in detection of unlabeled and ¹⁵N₂ -labeled L-tryptophan, L-kynurenine, serotonin and quinolinic acid in human and rat plasma by GC-MS
• as derivatization reagent in simultaneous analysis of cocaine, cocaethylene and their possible metabolic and pyrolytic products in blood, urine and muscle by GC-MS
• preparation of trifluoromethyl ynamines which, in turn, converted aldehydes to α-trifluoromethyl-α,β-unsaturated amides
• to generate fluorinated α-keto ethers with alkenes and has wide applications in the expanding fluorous research area

General Description

2,2,3,3,3-Pentafluoro-1-propanol is an alternative cleaning agent for chlorofluorocarbon.

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Fí.

Purification Methods

Shake the alcohol with alumina for 24hours, dry with anhydrous K2CO3, and distil it, collect the middle fraction (b 80-81o) and redistil it. [Beilstein 1 IV 1438.]