Pentafluoro-1-propanol
Synonym(s):PFPOH
- CAS NO.：422-05-9
- Empirical Formula: C3H3F5O
- Molecular Weight: 150.05
- MDL number: MFCD00004673
- EINECS: 207-012-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:12
What is Pentafluoro-1-propanol?
Chemical properties
clear colorless to slightly yellow liquid
The Uses of Pentafluoro-1-propanol
2,2,3,3,3-Pentafluoro-1-Propanol is a useful reagent for the preparation of (oxoindolinyl)ethers/benzoates via photochemical O-H functionalization reactions of cyclic diazoamides.
The Uses of Pentafluoro-1-propanol
2,2,3,3,3-Pentafluoro-1-propanol has been used:
- as derivatization reagent in detection of unlabeled and 15N2 -labeled L-tryptophan, L-kynurenine, serotonin and quinolinic acid in human and rat plasma by GC-MS
- as derivatization reagent in simultaneous analysis of cocaine, cocaethylene and their possible metabolic and pyrolytic products in blood, urine and muscle by GC-MS
- preparation of trifluoromethyl ynamines which, in turn, converted aldehydes to α-trifluoromethyl-α,β-unsaturated amides
- to generate fluorinated α-keto ethers with alkenes and has wide applications in the expanding fluorous research area
General Description
2,2,3,3,3-Pentafluoro-1-propanol is an alternative cleaning agent for chlorofluorocarbon.
Safety Profile
Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Fí.
Purification Methods
Shake the alcohol with alumina for 24hours, dry with anhydrous K2CO3, and distil it, collect the middle fraction (b 80-81o) and redistil it. [Beilstein 1 IV 1438.]
Properties of Pentafluoro-1-propanol
| Boiling point: | 80 °C748 mm Hg(lit.) |
| Density | 1.505 g/mL at 25 °C(lit.) |
| vapor pressure | 62.055-324.857hPa at 24.93-54.78℃ |
| refractive index | n |
| Flash point: | 80-81°C |
| storage temp. | Flammables area |
| form | Powder, Crystals and/or Chunks |
| pka | 12.45±0.10(Predicted) |
| Specific Gravity | 1.509 |
| color | White to off-white to light yellow |
| Water Solubility | Soluble in water.21.9 g/L at 25°C |
| BRN | 1743133 |
| CAS DataBase Reference | 422-05-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,2,3,3,3-Pentafluoro-1-propanol(422-05-9) |
| EPA Substance Registry System | 1-Propanol, 2,2,3,3,3-pentafluoro- (422-05-9) |
Safety information for Pentafluoro-1-propanol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Pentafluoro-1-propanol
| InChIKey | PSQZJKGXDGNDFP-UHFFFAOYSA-N |
Pentafluoro-1-propanol manufacturer
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