PD 166793

Synonym(s):(S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid);MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem

CAS NO.：199850-67-4
Empirical Formula: C17H18BrNO4S
Molecular Weight: 412.3
MDL number: MFCD09038565
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:38

What is PD 166793?

The Uses of PD 166793

PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system.

What are the applications of Application

PD166793 is a potent MMP-2, MMP-3, and MMP-13 inhibitor

General Description

A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC₅₀ = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC₅₀ = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

Biological Activity

Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

Biochem/physiol Actions

Cell permeable: yes

Storage

Desiccate at +4°C

Properties of PD 166793

Melting point:	192-193℃
Density	1.457
storage temp.	Sealed in dry,2-8°C
solubility	DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form	A crystalline solid
color	White to pink