PAC-1-d8

CAS NO.：1287241-26-2
Empirical Formula: C23H28N4O2
Molecular Weight: 392.49402
Update Date: 2023-05-15 10:43:35

What is PAC-1-d8?

The Uses of PAC-1-d8

Labelled PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.

Properties of PAC-1-d8

solubility	soluble in DMSO, Methanol
form	Solid
color	Off-White

Safety information for PAC-1-d8

Computed Descriptors for PAC-1-d8

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